RESEARCH
Microbial interactions with higher plants including organisms making antibiotics, antimycotics , anticancer agents, and compounds having other biological activities. Plant materials are sourced from the rainforests of the world.
AREA OF RESPONSIBILITY
Research on the discovery of novel endophytic fungi and bacteria and their products. Assistance provided to the NSF EPSCOR program and pat time teaching in the Biotech program.
EDUCATION
- B.S. Botany Colorado State University 1960
- Ph.D. Plant Pathology University of California 1963
MEMBERSHIPS IN PROFESSIONAL ASSOCIATIONS
- AAAS
- American Society of Biological Chemists and Molecular Biologists
RECENT PROFESSIONAL ACTIVITIES
- Director of NSF-EPSCoR
- Editorial Board Plant Physiology, Plant Science, Toxin Reviews and J. Nat. Toxins
PUBLICATIONS FROM 1998 TO PRESENT
Hoffman, A., Khan, W., Worapong, J., Strobel, G., Griffin, D, Arbogast, B., Borofsky, D., Boone, R.B., Ning, L., Zheng, P. and Daley, L. 1998. Bioprospecting for taxol in Angiosperm plant extracts. Spectroscopy 13: 22-32.
Li, J.Y., Sidhu, R., Bollon, A. and Strobel, G.A. 1998. The stimulation of taxol production in liquid cultures of Pestalotiopsis microspora Ne32. Mycol. Res. 102: 461-464.
Li, J.Y., Sidhu, R.S., Ford, E., Hess, W.M. and Strobel, G.A. 1998. The induction of taxol production in the endophytic fungus - Periconia sp. from Torreya grandifolia. J. Ind. Microbiol. 20: 259-264.
Long, D.M., Smidmansky, E.D., Archer, A.J. and Strobel, G.A. 1998. In vivo addition of telomeric repeats to foreign DNA generates chromosomal DNAs in the taxol-producing fungus Pestalotiopsis microspora. Fungal Genetics & Biol. 24: 335-344.
Pleban, S. and Strobel, G.A. 1998. Rapid evaluation of Fusarium sp. as a potential biocontrol agent for weeds. Weed Science. 46: 703-706.
Miller, C.M., Miller, R.V., Garton-Kinney, D., Redgrave, B., Sears, J., Condron, M., Teplow, D. and Strobel, G.A. 1998. Ecomycins, unique antimycotics from Pseudomonas viridiflava. J. Applied Microbiology 84: 937-944.
Strobel, Gary A. 1998. Biology in Pictures. Chemistry & Biol. 8: 295.
Strobel, Gary A. 1998. Fungal Endophytes. Proc. of the 1997 Biotechnology of Microbial Products - Developments in Ind. Microbiology 35: 69-71.
Strobel, G.A. and Long, D. 1998. Endophytic Microbes Embody Pharmaceutical Potential. ASM News 64: 263-268.
Bowyer, W.J., Ning, L., Daley, L.S., Strobel, G.A., Edwards, G.E. and Callis, J. 1998. In vivo fluorescent imaging for detection of damage to leaves by fungal phytotoxins. Applied Spectroscopy 13:36-44.
Sugawara, F., Uzawa, J., Esumi, Y., Suzuki, M. Yoshida, S., Strobel, G. Steiner, J.L. and Clardy, J. 1998. Phytotoxins from the Septoria spp. Plant Pathogenic Fungus on Leafy Spurge. Biosci. Biotech. Biochem. 62: 638-642.
Kim, S-U, Strobel, G., Ford, E. 1999. screening of total producing endophytic fungi: from Ginko biloba and Taxus cuspidata in Korea. Agric. Chem.. Biotechnol. 42: 97-99
Strobel, G.A., Ford, E., Li, J.Y., Sears, J., Sidhu, R.S. and Hess, W.M. 1999. Seimatoantlerium tepuiense gen. nov. A unique epiphytic fungus producing taxol from the Venezuelan Guayana. System.Appl. Microbiol 22: 426-433.
Strobel, G.A., Miller,R.V., Miller,C., Condron,M.., Teplow, D.B., and Hess, W.M., 1999. Cryptocandin, a potent antimycotic from the endophytic fungus Cryptosporiopsis cf. quercina Microbiol.145: 1919-1926.
Wilkinson, R.A., Strobel, G.A., and Stierle, A., 1999. Sphaeric acid, a new succinic acid derivative from Sphaeropsis sp. J. Nat. Prod. 62: 358-360.
Strobel, G., J.Y., Sugawana, F., Koshino, H., Harper, J., and Hess, W. M. 1999. Oocydin A, a chlorinated macrocyclic lactone with potent anti-oomycete activity from Serratia marcesens. Microbiol. 145: 3557-3564.
Bobylev, M.M., Bobyleva, L. I., and Strobel, G.A. 1999. Natural products containing phenylalanine as potent herbicides in Biological Active Natural Products: ed. H.G. and S.J. Cutler CRC Press Boca Raton Florida 299p.
Bashyal, B., Li, J.Y., Strobel, G.A., and Hess,W.M. 1999. Seimatoantlerium nepalense, an endophytic taxol producing coelomycete from Himalayan yew (Taxus wallachiana). Mycotaxon 72: 33-42.
Bobylev, M. M., Bobyleva L. I., Cutler H. G., Cutler S. J., and Strobel G. A. 1999. Growth regulating activity of maculosin analogs in the etiolated wheat coleoptile bioassay (Triticum aestivum L. cv. Wakeland). PGRSA Quarterly. 27:(4), 105-118.
Strobel, G.A. 2000. “Taxol” in Encyclopedia of Life Sciences. Macmillan Press. London.
Bobylev, M.M., Bobyleva, L.I., and Strobel, G.A. 2000. Effects of synthetic congers of the natural product phytotoxins- maculosin- 1 and –2 on growth of wheat coleptiles ( T. aestivum L.) International Conference on Biological Control, Bozeman, Mt 1999.
Metz, A., Haddad, A., Worapong, J., Long, D., Ford, E., Hess,W.M., and Strobel, G.A. 2000. Induction of the sexual stage of Pestalotiopsis microspora, a taxol producing fungus. Microbiol. 146: 2079-2089..
Wagenaar, M., Corwin, J., Strobel, G.A., and Clardy, J. 2000. Three new chytochalasins produced by an endophytic fungus in the genus Rhinocladiella. J.Nat. Prod.63: 1692-1695.
Strobel, G.A., Ford, E., Worapong, J., and Hess, W.M. 2000. Pestalotiopsis jesterii sp. nov. an endophyte from Fragraea bodeni from the southern highlands of Papua New Guinea.Mycotaxon. 76: 257-266.
Li, J., Strobel, G.A. Harper, J., Lobkovsky, E., and Clardy, J. 2000. Cryptocin, a potent tetramic acid antimycotic from the endophytic fungus- Cryptosporiopsis quercina. Org Lett. 2: 767-770.
Harper, J., Arif, A.M., Li, J.Y., Strobel, G.A., Grant, D.M. 2000. Terrein. Acta. Crystallographica. C56, e570-e571. .
Li, J.Y., Harper, J.K., Grant, D.M., Tombe, B., Bashyal, B., Hess.W.M., and Strobel, G.A. 2001. Ambuic acid, a highly functionalized cyclohexenone with bioactivity from Pestalotiopsis spp. and Monochaetia sp. Phytochem. 56: 463-468.
Strobel, G.A., Hess,W.M., Baird, G., Ford, E., Li, J.Y., and Sidhu, R.S. 2001. Stegolerium kukenani gen. nov. an endopyhtic, taxol producing fungus from the Roraima and Kukenan Tepuis of Venezuela. Mycotaxon 78: 353-361.
Acuna, I.A., Strobel, G.A., Jacobsen, B.J., and Corsini, D.L. 2001. Glucose conjugation as a mechanism of resistance to thaxtomin A in potatoes. Plant Science 161:77-88.
Shrestha, K., Strobel, G.A., Prakash, S., and Gewali, M. 2001. Evidence for paclitaxel from three new endophytic fungi of Himalayan yew of Nepal. Planta Medica 67: 374 –376.
Li, J.Y., and Strobel, G.A. 2001. Jesterone and hydroxy-jesterone antioomycete cyclohexenenone epoxides from the endophytic fungus- Pestalotiopsis jesteri. Phytochemistry 57: 261-265.
Worapong, J., Strobel, G.A., Ford, E. J., Li, J.Y., Baird, G., and Hess, W.M. 2001 Muscodor albus gen. et sp. nov. an endophyte from Cinnamomum zeylanicum Mycotaxon. 79: 67-79.
Strobel, G.A., Dirksie, E., Sears, J., and Markworth, C. 2001. Volatile antimicrobials from a Novel Endophytic Fungus. Microbiol. 147: 2943-2950..
Hu, Y., Chaomin, L., Kulkarni, B., Strobel, G., Lobkovsky, E., Torczynski, R., Porco, J., 2001 Exploring chemical diversity of epoxyquinoid natural products: synthesis and biological activity of jesterone and related molecules. Org. Lett. 3: 1649-1652.
Harper, J.K., Li, J.Y., Grant, D.M. and Strobel, G.A. 2001. Characterization of stereochemistry and molecular conformation using solid-state NMR tensors. J. Am .Chem. Soc. 123: 9837- 9842.
Metz, A., Love, R., Strobel, G.A., and Long, D.M. 2001. Two telomerase reverse transcriptases (TERTs) expressed in Candida albicans.Biotechnology and Applied Biochemistry 34: 47-54.
Shrestha, K., Banskota, A.H., Kodata, S., Shrivastava, S.P., Strobel G., and Gewali, M.B. 2001. An antiproliferative norditerpene dilactone, nagilactone C, from Podocarpus neriifolius. Phytomedicine 8: 489-491.
Strobel, G.A. 2002. Useful Products from Rainforest Microorganisms I. endophytes and taxol Agro-food industry Hi -Tech (in press).
Strobel, G.A. 2002. Useful Products from Rainforest Microorganisms II. unique bioactive products from endophytes. Agro-food Industry Hi – Tech (in press).
Strobel, G.A., Ford, E., Worapong, J., Harper, J.K., Arif, A.M., Grant, D.M., Fung, P., and Chau, R. M. W. 2002. Isopestacin, a unique isobenzofuranone from Pestalotiopsis microspora possessing antifungal and antioxidant properties. Phytochem. 60:179-183.
Worapong, J., Strobel, G.A., Daisy, B., Castillo,U., Baird, G., and Hess, W.M. 2002. Muscodor roseus anna. nov. an endophyte from Grevillea pteridifolia. Mycotaxon 81: 463-475.
Strobel, G.A. 2002. Microbial gifts from the rainforest. Can. J. Phytopath. 24:14-20.
Worapong, J Ford, E., Strobel, G., and Hess, W. M., 2002. UV- light induced conversion of Pestalotiopsis microspora to mutant biotypes with multiple conidial forms. Fungal Diversity 9:179-194.
Metz, A., Smidanski, E., Edlin, R., Strobel, G.A., and Long, D.M. 2001. Telomere structure of chromosomal and extrachromosomal DNAs of the taxol producing fungus Pestalotiopsis microspora. FEMS. (to be submitted).
Strobel, G.A. 2002. Rainforest endophytes and bioactive products. Critical Reviews in Biotechnology. (in press).
Castillo, U, Strobel, G.A., Ford, E.J.,. Hess, W.M., Porter, H., Jensen, J.B., Albert, H., Robison, R., Condron, M.A., Teplow, D.B., Stevens, D., and Yaver, D. 2002. Munumbicins, wide spectrum antibiotics produced by Streptomyces munumbi, endophytic on Kennedia nigriscans. Microbiology (in press).
Harper, J.K., Barich, D.H., Hu, J.Z., Strobel, G.A., and Grant, D.M. 2002. Stereochemical Analysis by Solid-State NMR: Structural Predictions in Ambuic Acid. J. Org. Chem.
Daisy, B., Strobel, G., Ezra, D., Castillo, U., Baird, G., and Hess, W.M. 2002.Muscodor vitigenus sp.nov. an endophyte from Paullinia paullinoides. Mycotaxon (in press).
Daisy, B.H., Gary A. Strobel, G.A., Castillo,U., Sears, J., Weaver, D.K., and Runyon, J.B. 2002. Naphthalene production by Muscodor vitigenus, a novel endophytic fungus. Microbiology (in press).
CURRENT PROGRAMS
Research
- The isolation of novel endophytic organisms and a determination if they or their products have economic and scientific potential.
Teaching
- Department seminar (PSPP 500) on occasion and part time in biotech.
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